Pharmacologic vitreolysis

The vitreoretinal interface is involved in a wide range of vitreoretinal disorders and separation of the posterior vitreous face from the retinal surface is an essential part of vitrectomy surgeries. A diverse range of enzymatic and non-enzymatic agents are being studied as an adjunct before or during vitrectomy to facilitate the induction of posterior vitreous detachment. There is a significant body of knowledge in the literature about different vitreolytic agents under investigation for a variety of pathologies involving the vitreoretinal interface which will be summarized in this review

Correlation between retinal nerve fiber layer thickness by optical coherence tomography and perimetric parameters in optic atrophy

To investigate the correlation between retinal nerve fiber layer [RNFL] thickness determined by optical coherence tomography [OCT] and visual field [VF] parameters in patients with optic atrophy. This study was performed on 35 eyes of 28 patients with optic atrophy. RNFL thickness was measured by OCT [Carl Zeiss, Jena, Germany] and automated perimetry was performed using the Humphrey Field Analyzer [Carl Zeiss, Jena, Germany]. The correlation between RNFL thickness and VF parameters was evaluated. Mean global RNFL thickness was 44.9 +/- 27.5] which was significantly correlated with mean deviation score on automated perimetry [r=0.493, P=0.003]; however, no significant correlation was observed between visual field pattern standard deviation and the corresponding quadrantic RNFL thickness. In a similar manner, no significant association was found between visual acuity and RNLF thickness. Mean global RNFL thickness as determined by OCT seems to be correlated with VF defect depth as represented by the mean deviation score on Humphrey VF testing. OCT may be used as an objective diagnostic tool in the evaluation of patients with optic atrophy